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A new ureido-substituted amino acid from the tubers of Gymnadenia conopsea

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A new ureido-substituted amino acid, conopsamide A (1), has been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea. Its structure was elucidated by extensive spectroscopic analysis, and… Click to show full abstract

A new ureido-substituted amino acid, conopsamide A (1), has been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea. Its structure was elucidated by extensive spectroscopic analysis, and the absolute configuration was assigned by Marfey's method. The new compound was evaluated for in vitro assay for HDAC1 (Histone Deacetylase 1) inhibitory activity.

Keywords: amino acid; new ureido; substituted amino; gymnadenia conopsea; tubers gymnadenia; ureido substituted

Journal Title: Chinese Chemical Letters
Year Published: 2017

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