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Effective preparation of 5,5’-(arylmethylene)bis(4-hydroxythiazole-2(3H)-one) in an aqueous fluoroalcohol solvent system under ultrasound irradiation at room temperature

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Abstract A green and convenient approach for the synthesis of a series of 5,5'-(arylmethylene)bis(4-hydroxythiazole-2(3H)-one) by the reaction of aryl aldehydes, monochloroacetic acid and ammonium thiocyanate in water/trifluoroethanol(TFE) (1:1) under ultrasound… Click to show full abstract

Abstract A green and convenient approach for the synthesis of a series of 5,5'-(arylmethylene)bis(4-hydroxythiazole-2(3H)-one) by the reaction of aryl aldehydes, monochloroacetic acid and ammonium thiocyanate in water/trifluoroethanol(TFE) (1:1) under ultrasound irradiation at room temperature is described. This method provides several advantages such as environmental friendliness, shorter time, excellent yields, and simple work-up procedure.

Keywords: irradiation room; ultrasound irradiation; hydroxythiazole one; bis hydroxythiazole; room temperature; arylmethylene bis

Journal Title: Chinese Chemical Letters
Year Published: 2017

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