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Abstract A new cytotoxic salannin-class limonoid alkaloid, azadiramide A (1), was isolated from seeds of Azadirachta indica A. Juss. Its structure was elucidated by extensive analysis of spectroscopic data and… Click to show full abstract
Abstract A new cytotoxic salannin-class limonoid alkaloid, azadiramide A (1), was isolated from seeds of Azadirachta indica A. Juss. Its structure was elucidated by extensive analysis of spectroscopic data and quantum chemical calculation. Compound 1 is a rare salannin-class limonoid alkaloid. To our best knowledge, only two compounds belonging to this type were so far found. It showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC50 value of 2.70 ± 0.63 μmol/L.
Keywords:
new cytotoxic;
salannin class;
limonoid alkaloid;
class limonoid
Journal Title: Chinese Chemical Letters
Year Published: 2017
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Journal Title: Chinese Chemical Letters
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!