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ABSTRACT We describe the development of dinuclear metallic ligands to target specific HIV RNA structures. Two series of dipyridinyl-N bridged dinuclear metal complexes were synthesized in moderate to good yields… Click to show full abstract
ABSTRACT We describe the development of dinuclear metallic ligands to target specific HIV RNA structures. Two series of dipyridinyl-N bridged dinuclear metal complexes were synthesized in moderate to good yields and their binding activities toward TAR and RRE RNA were studied both experimentally and theoretically. The docking calculation elucidated some structure features in dimetallic complexes that can affect TAR RNA-binding properties.
Keywords:
dinuclear metallic;
selective recognition;
rna;
metallic ligands;
hiv rna
Journal Title: Chinese Chemical Letters
Year Published: 2018
Link to full text (if available)
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Journal Title: Chinese Chemical Letters
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!