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Abstract α,β-Alkynyl ketoesters were introduced to the enantioselective Henry reaction (nitroaldol condensation) with nitromethane catalyzed by tartaric acid derived chiral iminophosphoranes. As such, a variety of optically active β-nitro-substituted tertiary… Click to show full abstract
Abstract α,β-Alkynyl ketoesters were introduced to the enantioselective Henry reaction (nitroaldol condensation) with nitromethane catalyzed by tartaric acid derived chiral iminophosphoranes. As such, a variety of optically active β-nitro-substituted tertiary alcohols bearing alkyne moieties were obtained in good to excellent yields (42%–99%) and moderate to good level of enantiomeric excess (up to 87% ee).
Keywords:
alkynyl ketoesters;
chiral iminophosphorane;
henry reaction
Journal Title: Chinese Chemical Letters
Year Published: 2019
Link to full text (if available)
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Journal Title: Chinese Chemical Letters
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!