LAUSR

Mg in MgAl-layered double hydroxides nanoparticles was substituted with different divalent transition metal ions (MAl-LDHs, M: Mg, Cu, Ni, Co, and Mn) via a facile method to be used as antibacterial agentsape The phase structural and morphological characterizations of MAl-LDHs were investigated by XRD, FTIR spectroscopy and TEM. The results have shown that all of MAl-LDHs had typical layered structures except MnAl-LDH which contained MnO phases. Particular morphology of MnAl-LDH with ellipsoids, spherical and rod-like structure and CuAl-LDH with rod-like shape existed. IC (the concentrations providing 50% antibacterial activity) values of CuAl-LDH, NiAl-LDH, CoAl-LDH, and MnAl-LDH in broth dilution tests were ∼800-1500 μg/mL. Dosages of CuAl-LDH, CoAl-LDH, and MnAl-LDH with >10 mm inhibition zone in disk diffusion tests were ∼150–300 μg/disk. Antibacterial mechanism of MAl-LDHs may be attributed to the synergistic factors including effected surroundings, surface interactions, morphology of particles, ROS and metal ions. The results indicate a facile method to synthesis LDHs based effective antibacterial agents with the potential application in the area of water treatment and antibacterial coating.