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Abstract An unprecedented chiral secondary amine-catalyzed [3 + 3] annulation of isatin N,N'-cyclic azomethine imines with α,β-unsaturated aldehydes was developed. This strategy allowed the construction of structurally novel spiro N-heterocyclic oxindole derivatives… Click to show full abstract
Abstract An unprecedented chiral secondary amine-catalyzed [3 + 3] annulation of isatin N,N'-cyclic azomethine imines with α,β-unsaturated aldehydes was developed. This strategy allowed the construction of structurally novel spiro N-heterocyclic oxindole derivatives in good yields (up to 91%) and good to excellent enantioselectivities (up to >99% ee), albeit with modest diastereoselectivities (up to 3.1:1 dr).
Keywords:
cyclic azomethine;
isatin cyclic;
azomethine imines;
spiro heterocyclic;
annulation isatin
Journal Title: Chinese Chemical Letters
Year Published: 2020
Link to full text (if available)
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Journal Title: Chinese Chemical Letters
Year Published: 2020
Link to full text (if available)
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recommendations!