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Abstract Chemoselective amine bioconjugation has long been a challenge for native protein modification. Inspired by Thiele’s seminal discovery, Li and co-workers recently developed an ortho-phthalaldehyde (OPA) based reagent for labeling… Click to show full abstract
Abstract Chemoselective amine bioconjugation has long been a challenge for native protein modification. Inspired by Thiele’s seminal discovery, Li and co-workers recently developed an ortho-phthalaldehyde (OPA) based reagent for labeling the amino group of a protein. Here we report an expeditious and scalable synthesis of a Li − Thiele reagent featuring an arene construction strategy. The reagent contains an alkyne side chain as a handle for secondary modification.
Keywords:
reagent;
bioconjugation;
scalable preparation;
amine;
thiele reagent;
expeditious scalable
Journal Title: Chinese Chemical Letters
Year Published: 2020
Link to full text (if available)
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Journal Title: Chinese Chemical Letters
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!