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Abstract A nickel(II)-catalyzed asymmetric alkylation of acyclic oxocarbenium ions generated in situ from corresponding acetals with carboxylic acid derivatives to prepare β-alkoxyl carbonyl moieties with diverse α-substituents has been disclosed.… Click to show full abstract
Abstract A nickel(II)-catalyzed asymmetric alkylation of acyclic oxocarbenium ions generated in situ from corresponding acetals with carboxylic acid derivatives to prepare β-alkoxyl carbonyl moieties with diverse α-substituents has been disclosed. The method exhibited broad scope of acetals and carboxylic acid derivatives with excellent enantioselectivity and good functional group compatibility, and can be conducted in a gram-scale without obvious loss of efficiency.
Keywords:
alkylation acyclic;
catalyzed asymmetric;
asymmetric alkylation;
carboxylic acid;
acid derivatives;
nickel catalyzed
Journal Title: Chinese Chemical Letters
Year Published: 2020
Link to full text (if available)
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Journal Title: Chinese Chemical Letters
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!