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Catalyst- and additive-free selective sulfonylation/cyclization of 1,6-enynes with arylazo sulfones leading to sulfonylated γ-butyrolactams

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Abstract A convenient and regioselective sulfonylation/cyclization of 1,6-enynes with arylazo sulfones has been developed to access a series of sulfonylated γ-butyrolactams. The present reaction could be efficiently conducted under catalyst-… Click to show full abstract

Abstract A convenient and regioselective sulfonylation/cyclization of 1,6-enynes with arylazo sulfones has been developed to access a series of sulfonylated γ-butyrolactams. The present reaction could be efficiently conducted under catalyst- and additive-free conditions, in which C–S and C-C bonds were selectively constructed in one-pot procedure.

Keywords: catalyst additive; enynes arylazo; cyclization enynes; sulfonylated butyrolactams; sulfonylation cyclization; arylazo sulfones

Journal Title: Chinese Chemical Letters
Year Published: 2020

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