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Abstract A new electrochemical strategy for trifluoromethylation/cyclization using TfNHNHBoc as a CF3 source was established. This approach was realized by the direct electrolysis of TfNHNHBoc under external oxidant-free and catalyst-free… Click to show full abstract
Abstract A new electrochemical strategy for trifluoromethylation/cyclization using TfNHNHBoc as a CF3 source was established. This approach was realized by the direct electrolysis of TfNHNHBoc under external oxidant-free and catalyst-free conditions, and afforded various trifluoromethylated oxindoles with good functional group compatibility and broad substrate scope. Preliminary mechanistic studies show that the reaction proceeds by a radical process.
Keywords:
cf3 source;
tfnhnhboc cf3;
trifluoromethylation cyclization;
catalyst free;
using tfnhnhboc
Journal Title: Chinese Chemical Letters
Year Published: 2021
Link to full text (if available)
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Journal Title: Chinese Chemical Letters
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!