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Abstract A facile and sustainable approach for the amination of benzothiazoles with KSeCN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded… Click to show full abstract
Abstract A facile and sustainable approach for the amination of benzothiazoles with KSeCN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles in up to 96% yield. A series of control experiments were performed, suggesting a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazoles
Keywords:
benzothiazoles ksecn;
primary aminobenzothiazoles;
iodine catalyzed;
amination benzothiazoles;
water
Journal Title: Chinese Chemical Letters
Year Published: 2021
Link to full text (if available)
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Journal Title: Chinese Chemical Letters
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!