LAUSR

Abstract With the development of oncology and bioanalytical chemistry, liquid biopsy emerges as their fruit and manages to bring perspective chance of healthcare. To date, several typical biomarkers (i.e circulating tumor cells, extracellular vesicles, circulating nuclei acids, etc) have been well-established as promising targets of liquid biopsy, and numerous methods, of which optical and electrochemical methods occupy in majority, have been proposed for the idealized detection of these targets. However, the advancements in this field are massive from cancer biology and analytical technology. Therefore, it is necessary to review these advancements from both medical and chemical sides. Here in this paper, our group, of which academic background from medicine and chemistry, aim to provide some comprehensive and in-depth summarization on contribution of optical and electrochemical methods to liquid biopsy, considering both the view of oncologist and analytical chemists. Besides, we will discuss the remaining challenges and future trend of this field in the end. We hope this review can be inspirational to researcher in this field and give helpful introduction to people from various research area.