LAUSR

Abstract This review focusses on the supramolecular interactions between metal–organic frameworks (MOFs) and included biomolecules. Examples demonstrating the utility of crystallography, spectroscopic techniques, and computational modelling for probing such interactions are highlighted. Key papers illustrating the importance of intraframework interactions to the structure, flexibility, and availability of functional groups in bioMOFs are also discussed. Finally, a range of case studies focussing on applications relating to biosensing, drug delivery, contaminant removal and enzyme immobilisation are discussed as a means of highlighting how the various characterisation techniques can work together to provide an enhanced understanding of the supramolecular chemistry involved and their effects on the application.