LAUSR

Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in ensuring appropriate segregation of homologous chromosomes also result in genetic recombination and shuffling of genes between each generation. During the first meiotic prophase, rapid telomere-led chromosome movements facilitate alignment and pairing of homologous chromosomes. Forces that produce these movements are generated by the cytoskeleton. Force transmission across the nuclear envelope is dependent upon LINC complexes. These structures consist of SUN and KASH domain proteins that span the two nuclear membranes. Together they represent a pair of links in a molecular chain that couples telomeres to the cytoskeleton. In addition to their force transducing role, LINC complexes also have essential functions ensuring the fidelity of recombination between homologous chromosomes. In this way, LINC complexes are now seen as playing an active and integral role in meiotic progression.