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A single calcium (Ca2+) binding site within the canonical EF-hand loop was thought to govern the stromal interaction molecule-1 (STIM1) structural changes that lead to activation of Orai1 Ca2+ channels.… Click to show full abstract
A single calcium (Ca2+) binding site within the canonical EF-hand loop was thought to govern the stromal interaction molecule-1 (STIM1) structural changes that lead to activation of Orai1 Ca2+ channels. Recent work by Gudlur et al., published in Nat Commun [9(1):4536], suggests that the STIM1 endoplasmic reticulum (ER) luminal domain has ∼5 additional Ca2+ binding sites, which underlie a surprising new proposal for Ca2+ sensing.
Keywords:
molecule five;
five senses;
interaction molecule;
stromal interaction
Journal Title: Cell calcium
Year Published: 2019
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Journal Title: Cell calcium
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!