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The outer mitochondrial membrane protein VDAC interacts with the ER protein IP3R via chaperone Grp75 to form a molecular complex that couples mitochondria to the ER and contributes to functional… Click to show full abstract
The outer mitochondrial membrane protein VDAC interacts with the ER protein IP3R via chaperone Grp75 to form a molecular complex that couples mitochondria to the ER and contributes to functional mitochondria-ER contacts (MERCs), essential for efficient calcium (Ca2+) transfer. A new study by Liu et al. identifies the PD protein DJ-1 as a component of the IP3R-Grp75-VDAC complex. DJ-1 ablation impairs mitochondria-ER association and Ca2+ crosstalk, and impacts the stability of the trio.
Keywords:
trio turned;
vdac;
vdac complex;
ip3r grp75;
grp75 vdac
Journal Title: Cell calcium
Year Published: 2020
Link to full text (if available)
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Journal Title: Cell calcium
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!