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Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis… Click to show full abstract
Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis by activating the CaMKKβ/VPS34 pathway, providing a new insight into the pathophysiological role of TRPML1 in human diseases.
Keywords:
trpml1 autophagy;
multiple facets;
facets trpml1
Journal Title: Cell calcium
Year Published: 2020
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Journal Title: Cell calcium
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!