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Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?

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Abstract The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication… Click to show full abstract

Abstract The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are currently available. Endo-lysosomal two-pore cation channels have now emerged as potential novel targets for SARS-CoV treatment.

Keywords: could endo; ion channel; sars cov2; channel achilles; lysosomal ion; endo lysosomal

Journal Title: Cell Calcium
Year Published: 2020

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