Photo by nci from unsplash
NAADP (nicotinic acid adenine dinucleotide phosphate) is a potent second messenger releasing Ca2+ from endolysosomes through two-pore channels (TPCs) and from the endoplasmic reticulum (ER) through type 1 ryanodine receptors… Click to show full abstract
NAADP (nicotinic acid adenine dinucleotide phosphate) is a potent second messenger releasing Ca2+ from endolysosomes through two-pore channels (TPCs) and from the endoplasmic reticulum (ER) through type 1 ryanodine receptors (RyR1). How NAADP activates these channels, whether directly or indirectly, has been a matter of debate for more than a decade. Now a protein has emerged possibly providing the missing link between TPCs/RyR1 and NAADP.
Keywords:
link intracellular;
link;
ca2 release;
jpt2 missing;
missing link;
intracellular ca2
Journal Title: Cell calcium
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Cell calcium
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!