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TRPA1 channel: New kid in the 'neurovascular coupling' town.

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The just-in time delivery of oxygen and nutrients to active brain regions to support function (functional hyperemia; FH) is mediated by not yet fully understood mechanisms collectively referred to as… Click to show full abstract

The just-in time delivery of oxygen and nutrients to active brain regions to support function (functional hyperemia; FH) is mediated by not yet fully understood mechanisms collectively referred to as 'neurovascular coupling' (NVC). In a recent publication (eLife 2021) Thakore et al. provide profound mechanistic insight how the capillary endothelial transient receptor potential ankyrin 1 (TRPA1) channel contribute to blood flow control and functional hyperemia in the brain.

Keywords: coupling town; channel new; new kid; neurovascular coupling; kid neurovascular; trpa1 channel

Journal Title: Cell calcium
Year Published: 2021

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