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Abstract Background To summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19. Methods Available publications were systematically explored on some databases and gray literature was examined.… Click to show full abstract
Abstract Background To summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19. Methods Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively. Results Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Although remdesivir has been used as a compassionate drug for treating COVID-19 patients, it has only moderate efficacy. Conclusion Although remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.
Journal Title: Clinical Epidemiology and Global Health
Year Published: 2020
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