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Converting Cold into Hot Tumors by Combining Immunotherapies

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In a small phase Ib study in this issue of Cell, Ribas et al. report that the combination of intralesional injection of a modified human herpes simplex virus and systemic anti-PD-1… Click to show full abstract

In a small phase Ib study in this issue of Cell, Ribas et al. report that the combination of intralesional injection of a modified human herpes simplex virus and systemic anti-PD-1 treatment resulted in a 62% response rate in patients with metastatic melanoma, accompanied by enhanced T cell infiltration in virus-injected lesions.

Keywords: converting cold; cold hot; combining immunotherapies; tumors combining; hot tumors

Journal Title: Cell
Year Published: 2017

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