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Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble… Click to show full abstract
Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction.
Keywords:
acetylation cytidine;
stability translation;
translation;
cytidine mrna;
mrna nat10;
nat10 regulates
Journal Title: Cell
Year Published: 2018
Link to full text (if available)
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Journal Title: Cell
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!