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It’s Hard to Teach an Old B Cell New Tricks

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Victora and colleagues challenge current perceptions that memory B cells readily participate in secondary germinal center reactions, allowing further modification of specificity upon reactivation. Rather, naïve B cells are the… Click to show full abstract

Victora and colleagues challenge current perceptions that memory B cells readily participate in secondary germinal center reactions, allowing further modification of specificity upon reactivation. Rather, naïve B cells are the predominant B cell type that populate secondary germinal centers. This work has important basic immunological and translational implications.

Keywords: teach old; new tricks; cell new; hard teach; old cell; cell

Journal Title: Cell
Year Published: 2020

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