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The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune… Click to show full abstract
The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory diseases, and hematologic and oncologic disorders, giving rise to a new class of drugs, JAK inhibitors (or Jakinibs).
Keywords:
stat signaling;
jak;
snapshot jak;
jak stat
Journal Title: Cell
Year Published: 2020
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Journal Title: Cell
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!