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Greater understanding of the events preceding neurodegeneration is needed to design effective preventive and therapeutic strategies. In this issue of Cell, Bowles et al. (2021) report cerebral organoids that reveal early… Click to show full abstract
Greater understanding of the events preceding neurodegeneration is needed to design effective preventive and therapeutic strategies. In this issue of Cell, Bowles et al. (2021) report cerebral organoids that reveal early events in frontotemporal dementia pathogenesis due to mutations in microtubule-associated protein tau (MAPT), shedding light on a novel mechanism involving abnormal splicing and glutamate signaling.
Keywords:
tau organoids;
tau;
neurodegeneration mutant;
mutant tau;
neurodegeneration;
modeling neurodegeneration
Journal Title: Cell
Year Published: 2021
Link to full text (if available)
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Journal Title: Cell
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!