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The shock-and-kill strategy reactivates HIV-1 latent reservoir for immune clearance. Einkauf et al. found that some HIV-1-infected cells that persist and proliferate have transcriptionally active HIV-1 in permissive chromatin. Silent proviruses… Click to show full abstract
The shock-and-kill strategy reactivates HIV-1 latent reservoir for immune clearance. Einkauf et al. found that some HIV-1-infected cells that persist and proliferate have transcriptionally active HIV-1 in permissive chromatin. Silent proviruses in repressive chromatin resist reactivation. Understanding HIV-1-chromatin interactions and how transcriptionally active HIV-1-infected cells survive is a pressing need.
Keywords:
hiv infected;
transcriptionally active;
hiv;
cells survive;
active hiv;
infected cells
Journal Title: Cell
Year Published: 2022
Link to full text (if available)
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Journal Title: Cell
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!