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G. Bauer,1 N. Fakhri,2 A. Kicheva,3 J. Kondev,4 K. Kruse,5,* H. Noji,6 D. Riveline,7,* T.E. Saunders,8 M. Thattai,9 and E. Wieschaus10,11 1The International Human Frontier Science Program Organization, 12 Quai Saint-Jean, 67080 Strasbourg, France 2Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3Institute of Science and Technology IST Austria, 3400 Klosterneuburg, Austria 4Department of Physics, Brandeis University, Waltham, MA 02454, USA 5Departments of Biochemistry and Theoretical Physics, University of Geneva, 1211 Geneva, Switzerland 6Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, Tokyo, 113-8656 Japan 7Laboratory of Cell Physics ISIS/IGBMC, CNRS and University of Strasbourg, Strasbourg, France 8Mechanobiology Institute and Department of Biological Sciences, National University of Singapore, Singapore, Singapore 9Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru, India 10Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA 11Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA *Correspondence: [email protected] (K.K.), [email protected] (D.R.) https://doi.org/10.1016/j.cels.2018.04.003