LAUSR

Abstract Tricalcium silicate (C3S) has been used for biomedical materials. It has good biocompatibility and the ability to self-set, allowing it to serve as a bone cement. After setting, C3S demonstrates some mechanical strength but is easily broken. γ-Polyglutamic acid (γ-PGA) is a natural, non-toxic, highly biocompatible and edible polymer. To improve the physical properties of tricalcium silicate cement, in this study, we prepared a γ-PGA/C3S composite bone cement and tested its properties. The C3S powder was synthesized by the sol-gel method and then mixed with different proportions of γ-PGA to form the solid agent. Moderate 10 wt% NaH2PO4 solution was subsequently added to form the composite bone cement. After characterizing the material and evaluating its biocompatibility in vitro, the potential of the composite to improve bone cement was investigated.