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Protein crystallization in a droplet-based microfluidic device: Hydrodynamic analysis and study of the phase behaviour

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S.K. acknowledges funding from the European Research Council under the ERC Starting Grant Agreement no. 677169–MicroParticleControl. F.C acknowledges FCT (postdoctoral fellowship [SFRH/BPD/96132/2013]) under the project POCI-01-0145-FEDER-006939 (Laboratory for Process Engineering,… Click to show full abstract

S.K. acknowledges funding from the European Research Council under the ERC Starting Grant Agreement no. 677169–MicroParticleControl. F.C acknowledges FCT (postdoctoral fellowship [SFRH/BPD/96132/2013]) under the project POCI-01-0145-FEDER-006939 (Laboratory for Process Engineering, Environment, Biotechnology and Energy – UID/EQU/00511/2013) funded by the European Regional Development Fund (ERDF), through COMPETE2020 – Programa Operacional Competitividade e Internacionalizacao (POCI) and by national funds, through FCT – Fundacao para a Ciencia e a Tecnologia. We thank OpenFoam developers and contributors for the use of their codes, especially Kevin van As from the Transport Phenomena Group (TU Delft). We also thank Vahid Kazemi Kamyab, Milad Mottaghi and Khurram Shazad for all the suggestions and discussions on the simulations.

Keywords: crystallization droplet; device hydrodynamic; droplet based; microfluidic device; protein crystallization; based microfluidic

Journal Title: Chemical Engineering Science
Year Published: 2018

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