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Bromodomains are protein domains that serve as "readers" of acetylated lysine marks and mediate DNA-templated processes. In this issue of Cell Chemical Biology, Olzscha et al. (2017) report that the CBP/p300… Click to show full abstract
Bromodomains are protein domains that serve as "readers" of acetylated lysine marks and mediate DNA-templated processes. In this issue of Cell Chemical Biology, Olzscha et al. (2017) report that the CBP/p300 bromodomains mediate the formation of amyloid-like aggregates and that inhibitors specific to these bromodomains reduce the degree of protein aggregation and mitigate HDAC inhibitor-induced cytotoxicity.
Keywords:
mediates amyloid;
p300 bromodomain;
bromodomain mediates;
formation;
biology;
cbp p300
Journal Title: Cell chemical biology
Year Published: 2017
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Journal Title: Cell chemical biology
Year Published: 2017
Link to full text (if available)
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recommendations!