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CBP/p300 Bromodomain Mediates Amyloid Formation.

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Bromodomains are protein domains that serve as "readers" of acetylated lysine marks and mediate DNA-templated processes. In this issue of Cell Chemical Biology, Olzscha et al. (2017) report that the CBP/p300… Click to show full abstract

Bromodomains are protein domains that serve as "readers" of acetylated lysine marks and mediate DNA-templated processes. In this issue of Cell Chemical Biology, Olzscha et al. (2017) report that the CBP/p300 bromodomains mediate the formation of amyloid-like aggregates and that inhibitors specific to these bromodomains reduce the degree of protein aggregation and mitigate HDAC inhibitor-induced cytotoxicity.

Keywords: mediates amyloid; p300 bromodomain; bromodomain mediates; formation; biology; cbp p300

Journal Title: Cell chemical biology
Year Published: 2017

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