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The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition.

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Ubiquitin-specific protease 7 is a validated anticancer target; thus, selective USP7 inhibitors are of great interest. In this issue of Cell Chemical Biology, Lamberto et al. (2017) and Pozhidaeva et al. (2017)… Click to show full abstract

Ubiquitin-specific protease 7 is a validated anticancer target; thus, selective USP7 inhibitors are of great interest. In this issue of Cell Chemical Biology, Lamberto et al. (2017) and Pozhidaeva et al. (2017) report important insights into the structural inhibitor-enzyme interplay, lighting the way toward the development of selective inhibitors.

Keywords: step forward; next step; specific protease; ubiquitin specific; biology

Journal Title: Cell chemical biology
Year Published: 2017

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