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SUMOylation is a post-translational modification with important roles in normal physiology and whose dysregulation is associated with human diseases. In this issue of Cell Chemical Biology, Li et al. (2019) describe… Click to show full abstract
SUMOylation is a post-translational modification with important roles in normal physiology and whose dysregulation is associated with human diseases. In this issue of Cell Chemical Biology, Li et al. (2019) describe a covalent, allosteric inhibitor of the SUMO E1 enzyme and demonstrate its anti-tumor activity in preclinical models of colorectal cancer.
Keywords:
covalent allosteric;
allosteric inhibitor;
biology;
inhibitor sumo
Journal Title: Cell chemical biology
Year Published: 2019
Link to full text (if available)
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Journal Title: Cell chemical biology
Year Published: 2019
Link to full text (if available)
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recommendations!