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In this issue of Cell Chemical Biology, Erdogan et al. (2020) describe a new CRISPR/Cas9-based strategy for performing directed evolution of mammalian proteins in situ. Using this technique to select functional… Click to show full abstract
In this issue of Cell Chemical Biology, Erdogan et al. (2020) describe a new CRISPR/Cas9-based strategy for performing directed evolution of mammalian proteins in situ. Using this technique to select functional mRuby3 variants within lysosomes, they identify mCRISPRed, a fluorescent protein that displays robust stability and activity at low pH.
Keywords:
crispr;
evolution;
lights situ;
biology;
crispr lights;
situ protein
Journal Title: Cell chemical biology
Year Published: 2020
Link to full text (if available)
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Journal Title: Cell chemical biology
Year Published: 2020
Link to full text (if available)
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recommendations!