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Stereospecific Synthesis of Phosphatidylglycerol Using a Cyanoethyl Phosphoramidite Precursor.

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Phosphatidylglycerols (PG) are a family of naturally occurring phospholipids that are responsible for critical operations within cells. PG are characterized by an (R) configuration in the diacyl glycerol backbone and… Click to show full abstract

Phosphatidylglycerols (PG) are a family of naturally occurring phospholipids that are responsible for critical operations within cells. PG are characterized by an (R) configuration in the diacyl glycerol backbone and an (S) configuration in the phosphoglycerol head group. Herein, we report a synthetic route to provide control over the PG stereocenters as well as control of the acyl chain identity.

Keywords: phosphoramidite precursor; stereospecific synthesis; synthesis phosphatidylglycerol; phosphatidylglycerol using; using cyanoethyl; cyanoethyl phosphoramidite

Journal Title: Chemistry and physics of lipids
Year Published: 2020

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