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Catalytic Asymmetric Hetero-ene Reaction for Direct Customizable Allylic Functionalization

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In a recent publication in Nature , Tambar and coworkers have reported a Lewis-acid-assisted Bronsted-acid-catalyzed asymmetric hetero-ene reaction that proceeds from internal alkenes with excellent enantio-, regio-, and E -olefin… Click to show full abstract

In a recent publication in Nature , Tambar and coworkers have reported a Lewis-acid-assisted Bronsted-acid-catalyzed asymmetric hetero-ene reaction that proceeds from internal alkenes with excellent enantio-, regio-, and E -olefin selectivity. Key to the success is the use of a sulfurimide enophile. Derivatization of the ene products affords various allylic compounds.

Keywords: asymmetric hetero; hetero ene; ene; ene reaction

Journal Title: Chem
Year Published: 2017

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