LAUSR

Summary Due to the enhanced nano-bio interactions, nanoparticles with a rough surface have attracted a great deal of attention in nanomedicine. However, the low surface area of the rough nanoparticles is not suitable for drug loading. It is still a great challenge to increase the surface area of the nanocarriers without affecting the rough surface architecture. Here, a dual-component asymmetric structured mesoporous “nanotruck” is rationally synthesized by the interfacial-energy-mediated anisotropic growth strategy. The nanotruck possesses distinguished dual domains of spherical SiO2 head with rough surface (rSiO2) as an “engine” for enhanced nano-bio interactions, and periodic mesoporous organosilica (PMO) nanorod with a high surface area of ∼ 794 m2/g as a “trailer” for efficient drug loading. By embedding a dual-mode up-downconversion luminescent nanoparticle in rSiO2 head, the nanotrucks exhibit not only unique intensive interaction with tumor cells, long blood circulation and efficient tumor accumulation, but also NIR bio-imaging-guided controllable drug release.