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1,2-Azide Migration Enables Synthesis of β-Difluoroalkyl Azides

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Reactions involving an azido group where the azide remains intact are rare and largely underexplored. In this issue of Chem, Bi and co-workers disclose a mild, functional-group-tolerant strategy for the… Click to show full abstract

Reactions involving an azido group where the azide remains intact are rare and largely underexplored. In this issue of Chem, Bi and co-workers disclose a mild, functional-group-tolerant strategy for the synthesis of β-difluoroalkyl azides from readily accessible α-vinyl azides via an unusual 1,2-azide migration pathway.

Keywords: synthesis difluoroalkyl; migration enables; difluoroalkyl azides; enables synthesis; azide migration

Journal Title: Chem
Year Published: 2020

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