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Multiplex PCR on the Bronchoalveolar Lavage Fluid of Immunocompromised Patients.

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Characteristic Value Age, y 57.63 14.73 Male sex 306 (58.6) Hospitalization (IQR), d 11 (3; 25) Symptoms and signs Cough 300 (57.5) Dyspnea 124 (23.8) Sputum 118 (22.6) Fever 108… Click to show full abstract

Characteristic Value Age, y 57.63 14.73 Male sex 306 (58.6) Hospitalization (IQR), d 11 (3; 25) Symptoms and signs Cough 300 (57.5) Dyspnea 124 (23.8) Sputum 118 (22.6) Fever 108 (20.7) Decrease in FEV1 % predicted 59 (11.3) Reasons for immunosuppression Allogenic HSCT 112 (21.5) Lung transplantation 83 (15.9) Other hematologic therapies 79 (15.1) Interstitial lung disease 59 (11.3) Connective tissue disease 52 (10.0) Chemotherapy 37 (7.1) Solid cancer 29 (5.6) HIV/AIDS 25 (4.8) Other conditions 20 (3.8) Renal transplantation 23 (4.4) Autologous HSCT 21 (4.0) Liver transplantation 5 (1.0) Treatment Systemic steroids 271 (51.9) Mycophenolate 154 (29.5) Tacrolimus 109 (20.9) Cyclosporine 75 (14.4) Chemotherapy 72 (13.8) Methotrexate 22 (4.2) Azathioprine 21 (4.0) Highly active antiretroviral agents 17 (3.3) (Continued) Pleural effusion 6 (1.1) Bronchiolitis 5 (0.96) Atelectasis 2 (0.38) Empyema and/or abscess 2 (0.38) Pleural plaques 1 (0.19) Cysts 1 (0.19) Macroscopic bronchoscopy findings No pathologic finding 193 (37.0) Erythema of the mucosa 167 (32.0) Purulent secretion 85 (16.3) Nonpurulent secretion 77 (14.8) Bloody secretion 40 (7.7) Endobronchial tumor 6 (1.1) Others 11 (2.1) Clinical final diagnosis Infection 320 (61.3) Nonpulmonary infection 122 (23.4) Progression of underlying disease 35 (6.7)

Keywords: immunocompromised patients; pcr bronchoalveolar; bronchoalveolar lavage; multiplex pcr; lavage fluid; fluid immunocompromised

Journal Title: Chest
Year Published: 2018

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