LAUSR

BACKGROUND Bloodstream infections (BSI) are common after hematopoietic stem cell transplantation (HSCT), and associated with increased long-term morbidity and mortality. However, short-term outcomes related to BSI in this population remain unknown. More specifically, it is unclear whether choices related to empiric antimicrobials for potentially infected patients are associated with patient outcomes. RESEARCH QUESTION Are potential delays in appropriate antibiotics associated with hospital outcomes among HSCT recipients with BSI? STUDY DESIGN AND METHODS We conducted a retrospective cohort study at a large comprehensive inpatient academic cancer center between January 2014 and June 2017. We identified all admissions for HSCT and prior recipients of HSCT. We defined potential delay in appropriate antibiotics as >24 hours between positive blood culture and the initial dose of an antimicrobial with activity against the pathogen. RESULTS We evaluated 2751 hospital admissions from 1086 patients. 395 (14.4%) admissions involved ≥1 BSI. Among these hospitalizations, 44 (11.1%) involved potential delays in appropriate antibiotics. The incidence of mortality was higher in BSI hospitalizations than in those without BSI (23% vs 4.5%, p < 0.001). In multi-variable analysis, BSI was an independent predictor of mortality (OR 8.14, 95% CI 5.06-13.1, p < 0.001). Mortality was higher for admissions with potentially delayed appropriate antibiotics than for those with appropriate antibiotics (48% vs 20%, p < 0.001). Potential delay in antibiotics was also an independent predictor of mortality in multi-variable analysis (OR 13.8, 95% CI = 5.27-35.9, p < 0.001). INTERPRETATION BSI were common and independently associated with increased morbidity and mortality. Delays in administration of appropriate antimicrobials were identified as an important factor in hospital morbidity and mortality. These findings may have important implications for our current practice of empiric antibiotic management in HSCT patients.