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TOPIC: Obstructive Lung Diseases TYPE: Original Investigations PURPOSE: Chronic obstructive pulmonary disease (COPD) course with air trapping that causes respiratory symptoms that limit the activities of daily living. In patients with SARS-COV2 infection, symptoms increase and the clinical condition worsen, increasing the complications and mortality. Aim: To describe the clinical condition and symptoms of patients with COPD and COVID-19. METHODS: Cross-sectional descriptive study in patients with a medical diagnosis of COPD and who presented coronavirus infection confirmed by PCR during February 2021 in a clinic in Cali, Colombia. Institutional ethics endorsement and informed consent were obtained from the participants. Sociodemographic, clinical and symptoms variables were taken 21 days after the onset of the patients' symptoms by personal interview and telephone call. RESULTS: 18 patients with chronic obstructive pulmonary disease and coronavirus infection were linked to the study. The mean age of the patients was 67.4±17.1, the sex distribution was higher for men 66.7%. The place where they made the recovery corresponded in 61.1% at home, 33.3% Hospitalization and 5.6% in the intensive care unit. The most frequent GOLD classification was A (33.3%), C (27.8%), B (22.2%), D (16.7%). Only 16.3% used home oxygen and 27.8% corticosteroids. The most frequent comorbidity was arterial hypertension (33.3%), 5.6% of the patients had a smoking habit. Respiratory failure occurred in 3 patients (16.7%). The most frequent respiratory symptoms were cough 61.1%, fever 50%, adynamia 44.4% and respiratory distress 38.9%. CONCLUSIONS: Patients with chronic obstructive pulmonary disease who presented coronavirus infection present a greater distribution in men, they recover at home mainly although one third have respiratory failure treated in the clinic, most of them have A GOLD classification, the most prevalent comorbidity is hypertension and the most frequent symptoms are cough and fever represented in more than half of the patients. CLINICAL IMPLICATIONS: The identification of complications in COPD patients with coronavirus infection implies knowledge of the high probability of presenting respiratory failure associated with comorbidities such as arterial hypertension. In turn, the symptoms in COPD patients could better guide respiratory care to avoid future complications. DISCLOSURES: No relevant relationships by Juan Carlos Avila-Valencia, source=Web Response No relevant relationships by Vicente Benavides, source=Web Response No relevant relationships by Jhonatan Betancourt-Peña, source=Web Response No relevant relationships by Jenifer Rodríguez-Castro, source=Web Response