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TOPIC: Chest Infections TYPE: Original Investigations PURPOSE: Studies comparing the relationship between ethnicity and overall outcomes in individuals infected with COVID-19 have yielded diverse results. We conducted a retrospective observational study on hospitilized patients with COVID-19 at an urban hospital in New Jersey. We assesed for differences in clinical outcomes including mortality, need for invasive mechanical ventilation and length of stay based on ethnicity. METHODS: This was a retrospective observational study conducted at Saint Joseph’s University Hospital in Paterson, New jersey. The study was conducted from September 1, 2021 to November 30,2021 and was based on auditing electronic medical records who were admitted to the hospital with a diagnosis of COVID-19. Patients included in the study were male and females at least 18 years old who had a confirmed diagnosis with COVID-19 with PCR. Statistical analysis was performed with chi-squared analysis for categorical variables and Anova for continuous variables, statistics were performed in R language. RESULTS: A total of 440 patients were included in the study, of which 236 were Hispanic (50.3%), 131 were Caucasian (27.1%), 47 were African American (10.7%) and 26 were Asian (5.9%). Cuacasians had the higest mortality rate (21/131 [16%]), followed by hispanic (33/236 [13.9%]), Asian (3/26 [11.5%]), and african american (3/47 [6.3%]). Asians had the highest rate of intubation (5/26 [19.2%]) followed by Hispanic (29/236 [12.2%]), Caucasian (13/131 [9.9%]) and African American (2/47 [4.2%]). In regards to lengths of stay, the mean lentgh of stay for Caucasians was 8 (5-12), Hispanic 8( 5-13), African American 6 (5-12) and Asian 8 (5-17). There were no statistically significant differences noted in terms of mortality, need for invasive mechanical ventilation, or length of stay between all ethnicity groups (P > 0.05). CONCLUSIONS: In our study, there are no statistically significant differences when comparing mortality, need of invasive mechanical ventilation or length of stay between all of the ethnic groups. CLINICAL IMPLICATIONS: While there were no statistically significant differences in the various outcomes based on ethnicity in our study, more research is needed to further investigate this topic. Various other studies performed in the US have produced conflicting evidence on the impact of ethnicity on outcomes with COVID-19. Our study was limited to a relatively small sample size and the phase of the pandemic which may have affected the results. To further understand the varying degress of disease burden across ethnicities it may be useful to gather data on the biological interaction of SARS-COV2 on different ethnic groups, as well detailed in-hospital comparisons of management used to treat these patients. Reviewing these management plans may allow an in-depth assessment of the treatment modalities being used in specific patient populations, and may bring to light any racial or geographical disparities that affect their treatment during their hospital stay. DISCLOSURES: No relevant relationships by Rajapriya Manickam, source=Web Response No relevant relationships by Ashesha Mechineni, source=Web Response No relevant relationships by Christopher Millet, source=Web Response No relevant relationships by Spandana Narvaneni, source=Web Response