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Topography of Schwann cell with atomic force microscope

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Abstract The peripheral nerve injury is very common, its repair and regeneration is a significant challenge in nerve tissue engineering. Schwann cells cytoskeleton remolding for the migration, myelination, and directional… Click to show full abstract

Abstract The peripheral nerve injury is very common, its repair and regeneration is a significant challenge in nerve tissue engineering. Schwann cells cytoskeleton remolding for the migration, myelination, and directional neurites outgrowth, in the peripheral nerve system (PNS), increases its importance to investigate. In this study, we used an atomic force microscope (AFM) to investigate the live and fixed RN-22 Schwann cell topography. We provided the RN-22 Schwann cell cytoskeleton structural variation within the cell. A comparison was made between the live and fixed RN-22 Schwann cell cytoskeleton structural details. This study may help for a better understanding of PNS.

Keywords: force microscope; schwann cell; topography; schwann; atomic force

Journal Title: Chinese Journal of Physics
Year Published: 2020

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