LAUSR

Abstract In developing new generations of coatings for drug and drug controlled release, there is a need for self-assembled materials that provide controlled sequential release of multiple therapeutics, while provide a tunable approach to time dependence and the potential for sequential or staged release. Herein, we demonstrated the ability to develop a self-assembled, in ciprofloxacin intercalated montmorillonite (CIP-Mt), the release rate and amount of interlayer ciprofloxacin (CIP) could be controlled by modifying the layer charge of montmorillonite (Mt). Compared with common sustained release materials, this composite had better effect on antibacterial and disinfection. The CIP-Mt system effectively blocked diffusion-based release, leading to approximately 50% reduction in bolus doses and 10-fold increase in the release timescale. Mt was a non-toxic and non-polluting sustained release material, could be applied to drug release research, and the release rate and time of its interlayer CIP can be controlled by modifying layer charge.