LAUSR

Background Recently there are efforts to use sentinel lymph node biopsy (SLNB) techniques after neoadjuvant chemotherapy (NAC) to minimize axillary surgery. However, studies have shown higher false negative rates in this scenario, which might result in inaccurate assessment of treatment response and patient prognosis as well as leaving residual disease behind. In this study, we describe the use of reflector‐guided excision of the percutaneously biopsied node (PBN) as an aid to conventional SLNB and its predictor of the axillary status after NAC. Patients and Methods This was a single‐institution analysis of patients who underwent axillary fiducial‐reflector placement and subsequent SLNB compared with conventional SLNB. Results Nineteen patients in the reflector group were matched with 19 patients who underwent conventional SLNB (conventional group). The PBN was identified in the SLNB in 19 patients (100%) in the reflector group and in 9 patients (47.3%) in the conventional group (P = .002). In the remaining 10 patients in the conventional group, the PBN was identified in the axillary lymph node dissection specimen in 4 patients (21%) and not identified in 6 patients (31.7%). Among the 38 patients, traditional mapping failed to identify the PBN in 13 patients (34.2%). The PBN was negative in 10 patients (36%) and positive in 18 patients (64%); no additional positive nodes were identified among patients with a negative PBN, correctly reflecting the status of the axilla in 100% of cases. Conclusion Mapping failure after NAC might compromise SLNB. Reflector‐guided excision of the PBN is not only facile and feasible, but more accurately reflects the status of the axilla after NAC. Micro‐Abstract Breast cancer patients with nodal involvement often undergo neoadjuvant chemotherapy. The previously biopsied node (PBN) provides the most accurate information regarding treatment response. This study aimed to evaluate the success of a reflector‐guided excision of the PBN to predict the response of the axilla. The reflector described in this report effectively targets the PBN without institutional safety concerns, and reflects the status of the axilla in all cases.