LAUSR

Abstract The ability to predict patients with stage II colon cancer at high risk of recurrence is currently limited to certain clinicopathologic factors. This population-based study reviewed various prognostic factors to identify those associated with worse time to recurrence (TTR) and improved disease specific survival (DSS), and to subsequently develop a prognostic index (PI) to identify high risk cancers. Multivariate analyses revealed factors significant for TTR and DSS. A PI derived from the TTR risk factors identified 3 risk groups using 5-year rate without relapse: 88% for low-risk, 81% for intermediate-risk, and 59% for high-risk. This model was better at identifying high risk patients than using equally weighted standard risk factors.