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The optimal perioperative chemotherapy regimen in localized bladder cancer is still unknown. The cisplatin-gemcitabine regimen is a reasonable alternative to accelerated methotrexate, vincristine, cisplatin, and adriamycin in this setting in… Click to show full abstract
The optimal perioperative chemotherapy regimen in localized bladder cancer is still unknown. The cisplatin-gemcitabine regimen is a reasonable alternative to accelerated methotrexate, vincristine, cisplatin, and adriamycin in this setting in terms of efficacy. Gemcitabine is a prodrug transformed into active metabolites; however, 90% of gemcitabine is inactivated by cytidine deaminase. The assessment of serum cytidine deaminase activity can identify patients at high risk of gemcitabineinduced severe hematologic toxicity that can result in treatment delay and dose intensity reduction.
Journal Title: Clinical Genitourinary Cancer
Year Published: 2017
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