LAUSR

Micro‐Abstract The purpose of the present study was to assess whether ethnicity can affect the oncologic outcomes of primary prostate cryotherapy. After a 2‐group matched‐pair analysis of 327 men, the oncologic outcomes of primary cryotherapy as a treatment modality for primary, clinically localized prostate cancer was similar among men of African‐American descent and non–African‐American descent. Background African‐American (AA) men have the greatest incidence of and disease‐specific mortality from prostate cancer of any racial group. Although encouraging oncologic and functional outcomes have been reported with prostate cancer cryotherapy, little is known about how ethnicity can potentially affect the oncologic outcomes of primary cryotherapy. We report the oncologic outcomes of primary cryotherapy in AA patients through a matched‐pair analysis. Patients and Methods A 1:2 (AA to non‐AA) cohort of patients was designed using the Cryo‐On‐Line Data Registry. The 2 arms were matched for patient age, prostate‐specific antigen level, Gleason score, and prostate volume. The oncologic outcome was defined in terms of the biochemical recurrence (BCR) rates after primary cryoablation using Phoenix criteria. The results of “for‐cause” post‐treatment biopsies and the BCR‐free survival rates were also analyzed between the 2 groups. Results The 1:2 cohort of AA and non‐AA men in the present study included 109 and 218 men, respectively. Their median age (69 vs. 71 years; P = .71), median prostate‐specific antigen level (6.5 vs. 6.8 ng/mL; P = .95), median prostate volume (32 vs. 30 cm3; P = .31), Gleason score distribution (P = .97), and prostate cancer risk group (P = .12) were similar statistically. The median postoperative follow‐up period was also comparable between the 2 groups (AA, 32 months vs. non‐AA, 27 months; P = .52). The BCR rates were similar between the AA and non‐AA men (14% vs. 17%; P = .52). Likewise, the rate of positive “for‐cause” prostate biopsy findings was similar between the 2 groups (AA vs. non‐AA, 25% vs. 36%; P = .44). Furthermore, the 5‐year biochemical relapse‐free survival rates were comparable for the AA and non‐AA patients (74% vs. 71%; P = .37). Conclusion When matched for tumor characteristics, cryotherapy as a treatment modality for primary, clinically localized prostate cancer offers men of African‐American descent similar oncologic outcomes to those of non‐AA men.