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MicroRNA-128b mediates lipopolysaccharide-induced apoptosis via reactive oxygen species in human pulmonary microvascular endothelial cells

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Highlights • We observed that miR-128b regulated LPS-induced apoptosis of HPMECs and identified its mechanism.• LPS induced apoptosis and ROS production and upregulated miR-128b and caspase-3 expressions in HPMECs.• miR-128b… Click to show full abstract

Highlights • We observed that miR-128b regulated LPS-induced apoptosis of HPMECs and identified its mechanism.• LPS induced apoptosis and ROS production and upregulated miR-128b and caspase-3 expressions in HPMECs.• miR-128b has a potential therapeutic target for the treatment of ARDS.

Keywords: apoptosis; mediates lipopolysaccharide; microrna 128b; induced apoptosis; mir 128b; 128b mediates

Journal Title: Clinics
Year Published: 2022

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